Mark Twain Brewing Company

422 North Main St. • (573) 406-1300

At Mark Twain Brewery Co., we are proud to be a part of the  growing culture of brewers and beer drinkers, devoted to the traditional craft of brewing, and are now bringing these styles back, as they were originally meant to be enjoyed. We are northeast Missouri’s local and independent craft brewery.

Local Hannibal brewed beer is available in to-go growlers, 750 mls and 6-pack cans. Enjoy scenic river views from our upstairs Pilot House Bar or outdoor Rooftop Patio. Serving lunch and dinner with daily food specials.